Although vaccines are the cornerstone of controlling epidemics and saving lives, antivirals also have a key role to play in controlling the progression of diseases by reducing viral loads and could be used to break SARS-CoV-2 community transmission chains by limiting viral shedding levels and duration. In this chapter, we review the unprecedented international efforts and strategies, which took place over the last 12 months to screen and identify new antiviral treatments against SARS-CoV-2

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... cation for inclusion in COVID-19 clinical trials. We discuss the importance of long-range planning and sustaining our translational research focus to deepen our understanding of human coronaviruses (hCoVs) molecular pathogenesis. The latter is crucial to identify and validate novel targets for therapeutic interventions, in particular those commonly shared by hCoVs, and expand the repertoire of Broad-Spectrum Antiviral Agents (BSAA), enabling prompt deployment for current and future pandemics.Please send your comments on this content to monograph@ersnet.org