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The aim of this study was to generate and evaluate the efficiency of improved field experiments while simultaneously accounting for spatial correlations and different levels of genetic relatedness using a mixed models framework for orthogonal and non-orthogonal designs. Optimality criteria and a search algorithm were implemented to generate randomized complete block (RCB), incomplete block (IB), augmented block (AB) and unequally replicated (UR) designs. Several conditions were evaluateddoi:10.3390/agronomy8040040 fatcat:mcc5kdiv7jal7fndkq4o6wa73u