Recovery of nigrostriatal dopaminergic system insufficiency by allotransplantation of embryonic brain tissue

Olga Berchenko, Yelena Usmentseva
2013 World Journal of Neuroscience  
In an experiment in rats with electrolytic lesion of the compact part of substantia nigra (SN) and after allotransplantation of the embryonic tissue of SN in the caudate nucleus the features of movement and emotional behavior in the Open Field Test (OFT), the rotation movements caused by an administration of amphetamine, a content of catecholamines in the caudate nucleus, hypothalamus and blood plasma have been investigated. It is shown that the electrolytic lesion causes violations of the
more » ... lations of the statokinetic reflexes, the horizontal and the vertical movement activity, enhances the rotatory behavior, slow the orienttate-searching and the emotional reactions that combined with disbalance in dopamine-and noradrenalinetransmitter systems functioning. Allotransplantation of the embryonic dofaminsynthesizing brain tissue contributes to the restoration of movement activeity and its specific neurotransmitter ensuring.
doi:10.4236/wjns.2013.34032 fatcat:wkdkev4tdzahhc4bus4o7dswea