Can ventilation while on cardiopulmonary bypass improve post-operative lung function for patients undergoing cardiac surgery?

H. A. Vohra
2005 Interactive Cardiovascular and Thoracic Surgery  
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether ventilation during cardiopulmonary bypass (CPB) improves post-operative lung function. Altogether 187 relevant papers were identified using the below mentioned search, 9 papers represented the best evidence to answer the question. The author, journal, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses were
more » ... weaknesses were tabulated. We conclude that a wide range of ventilatory strategies, while on cardiopulmonary bypass, have been attempted including CPAP with positive airway pressures of 5-15 cm H O, high frequency low volume ventilation (with 100 breaths per min), inspired oxygen concentrations from 21% to 100% and 2 bilateral extra-corporeal circulation using the lungs to oxygenate the blood while on bypass. While some small and transient benefits for CPAP with 10 cm H O have been demonstrated, no convincing clinical benefits for any of these strategies have been shown and thus 2 ventilation while on cardiopulmonary bypass cannot be supported as a strategy to improve post-operative lung function.
doi:10.1510/icvts.2005.114710 pmid:17670453 fatcat:yo65tokdyjdvvlgkl253u5bxju