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Hospital Length of Stay in the First 100 Days after Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia in Remission: Comparison Among Alternative Graft Sources

Karen K. Ballen, Navneet S. Majhail, Ruta Brazauskas, Zhiwei Wang, Mahmoud D. Aljurf, Christopher Dandoy, Haydar A. Frangoul, Cesar O. Freytes, Hillard M. Lazarus, Charles F. LeMaistre, Susan K. Parsons, Franklin O. Smith (+5 others)
2014 Biology of Blood and Marrow Transplantation  

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between UCB and MMUD for bacterial infections (p ¼ .18) nor fungal infections (p ¼ .52); however, UCB recipients had significantly more viral infections compared to MMUD (p <.0001).The rate (infections per patient per year) of CMV reactivation/disease and adenoviral infections was higher in UCB recipients; MMUD had a higher rate of EBV reactivation (Table 2) . Infection as a cause of death was similar among the three graft sources at 1 year (41%, 31%, and 38% for UCB, MUD, and MMUD
more » ... . Overall survival at 1 year was 50% (46 e 55%), 69% (65 e 72%), and 58% (52 e 64%) for UCB, MUD, and MMUD respectively (p <.0001) and this difference was driven by higher treatment related mortality (TRM) as relapse was similar across the groups. The survival was slightly higher with MMUD compared to UCB (p<.04). In conclusion, 1) The incidences of bacterial, fungal, and particularly viral infections are high after alternative donor transplant; 2) Infections are a major cause of death in the first year after alternative donor transplant; 3) The incidence of infection as cause of death was similar among the graft sources; 4) Viral infections are higher in recipients of UCB compared to MMUD. Future directions will focus on preventative techniques and predictors for infection, particularly for viral infections.
doi:10.1016/j.bbmt.2013.12.119 fatcat:24gdzqzw6vc6niso6xjy2hzxoq
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Karen K. Ballen, Navneet S. Majhail, Ruta Brazauskas, Zhiwei Wang, Mahmoud D. Aljurf, Christopher Dandoy, Haydar A. Frangoul, Cesar O. Freytes, Hillard M. Lazarus, Charles F. LeMaistre, Susan K. Parsons, Franklin O. Smith, Amir Steinberg, David Szwajcer, Celalettin Ustun, William A. Wood, Steven Joffe. "Hospital Length of Stay in the First 100 Days after Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia in Remission: Comparison Among Alternative Graft Sources." Biology of Blood and Marrow Transplantation 20.2 (2014) S92