Knockdown of ZNF280A inhibits the development and progression of ovarian cancer [post]

Dawei Zhu, Xing Gu, Li Li, Xuebing Chen, Jie Huang
2020 unpublished
Background Ovarian cancer (OC) is one of the leading causes of death from gynecological malignancies worldwide. Abnormal expression of zinc finger proteins has been extensively reported to be involved in malignant progression in a variety of cancers. However, clinical significance and biological roles of ZNF280A in the field of OC are poorly known. Methods In this study, we demonstrated that ZNF280A was highly expressed in OC tissues compared with adjacent normal tissues. Further, ZNF280A was
more » ... ther, ZNF280A was positively associated with clinical staging, infiltration, lymphatic metastasis, metastasis, and tumor recurrence of OC patients. Additionally, data of in vitro experiments indicated that knockdown of ZNF280A by its shRNA dramatically reduced the proliferation and migration ability of OC cells, while enhancing the cell apoptosis. Results It was also verified by animal experiments that ZNF280A silencing would affect the growth of OC in vivo. Our study investigated the involvement of ZNF280A in the prognosis, progression and metastasis of OC. Conclusions Therefore, ZNF280A was identified as an optional prognostic factor in OC patients and can be used as a potential therapeutic target for the treatment of OC.
doi:10.21203/rs.3.rs-27424/v1 fatcat:wkh2e4qjljekpgwegpymegerdu