Original Article Changes in serum cytokines and vitamin D in Saudi postmenopausal women with osteoporosis

Nasser Al-Daghri, Sobhy Yakout, Naji Aljohani, Yousef Al-Saleh, Omar Al-Attas, Philip Mcternan, Majed Alokail
2017 Int J Clin Exp Med   unpublished
Accelerated bone loss has been observed in patients with inflammatory disorders, exacerbated with Vitamin D deficiency, whilst the impact of cytokines in the etiology of osteoporosis is unclear. However, the elucida-tion of this potential relationship could provide new insights to identify patients at early risk of osteoporosis as well as support the use of cytokine-based antibody therapies as potential interventions to reduce bone loss. The aim of the study was to determine the relationship
more » ... the relationship between pro-and anti-inflammatory cytokines with bone loss in Saudi post-menopausal women with and without osteoporosis. Further to understand the relative importance of Vitamin D on changes in inflammatory cytokine status. For this study post-menopausal women with (n=101) and without osteoporosis (n=120) were recruited. Anthropometric was taken along with fasted blood to measure 25-hydroxyvi-tamin D [25(OH)D] and cytokines (TNF-α, TGF-β, IL-1β, IL-4, IL6, Leptin, adiponectin, resistin, PAI-1, Lipocalin). Data shows a significantly lower plasma TGF-β (P<0.001) and serum IL-4 (P<0.001) and a significantly higher serum resis-tin (P<0.001) in the osteoporosis patients compared with control. Vitamin D showed a significant negative association with resistin (P=0.024). The osteoporosis group displayed a pro-inflammatory state with elevated serum levels of IL-6, leptin, IL-1. Other Inflammatory biomarkers were not associated with vitamin in postmenopausal women. In conclusions, the present study showed that inflammatory factors, such as resistin, TGF-β and IL-4 may play an important role in bone metabolism in postmenopausal women with osteoporosis. It is important to understand the balance between pro and anti-inflammatory cytokines as the impact to lower anti-inflammatory cytokines may allow pro-inflammatory cytokines to have more of an impact, coupled with elevated resistin levels.