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Knowledge of population thymidylate synthase (TS) levels in malignant tumors and normal tissues is essential for the use of TS as a predictor for 5-fluorouracil treatment. Tumor tissue TS levels in fresh frozen surgical biopsies from 136 patients with gastrointestinal or breast cancer, not previously subjected to chemotherapy, were analysed by [ ' I 4 FdUMP radioligand binding assay. TS levels were 2.4 f 0.31 pmol/g in liver metastases of colorectal cancer (n= 87), 4.2 f 1.0 pmol/g in primarydoi:10.3109/02841869609109924 pmid:8695163 fatcat:3tjvdxne75gpnlrodxgjczsppu