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Thymidylate Synthase in Advanced Gastrointestinal and Breast Cancers
1996
Acta Oncologica
Knowledge of population thymidylate synthase (TS) levels in malignant tumors and normal tissues is essential for the use of TS as a predictor for 5-fluorouracil treatment. Tumor tissue TS levels in fresh frozen surgical biopsies from 136 patients with gastrointestinal or breast cancer, not previously subjected to chemotherapy, were analysed by [ ' I 4 FdUMP radioligand binding assay. TS levels were 2.4 f 0.31 pmol/g in liver metastases of colorectal cancer (n= 87), 4.2 f 1.0 pmol/g in primary
doi:10.3109/02841869609109924
pmid:8695163
fatcat:3tjvdxne75gpnlrodxgjczsppu