Utility of Nickel for Atomic Absorption Spectrophotometric Determination of Selected Acidic Drugs

Hesham Salem, Khadiga Kelani, Abdalla Shalaby
2001 Scientia Pharmaceutica  
A simple and accurate method is described for the quantitative determination of flufenamic acid, mefenamic acid, tranexamic acid, furosemide, diclofenac sodium and thiaprofenic acid by precipitation reactions with nickel(II) followed by direct determination of the ions in the precipitate or indirect determination of the ions in the filtrate by atomic absorption spectroscopy. Statistical analysis of the results compared to assays used in pharmacopeas and the Amax. methods revealed equal
more » ... aled equal precision and accuracy. Furthermore the assays were also applied for the determination of these drugs in pharmaceutical preparations.
doi:10.3797/scipharm.aut-01-20 fatcat:e3qhkxfkrzatrayzflw6p7cvbm