Terminamines K–S, Antimetastatic Pregnane Alkaloids from the Whole Herb of Pachysandra terminalis

Xiang-Yu Li, Yang Yu, Miao Jia, Mei-Na Jin, Nan Qin, Chuan Zhao, Hong-Quan Duan
2016 Molecules  
Nine new pregnane alkaloids (1-9), together with eight known alkaloids (10-17), were isolated from the whole herb of Pachysandra terminalis. Their structures were elucidated on the basis of spectroscopic analyses. In addition, the isolates were examined for their ability to inhibit the migration of MDA-MB-231 cells induced by the chemokine epidermal growth factor (EGF). Alkaloids 1, 5, 7, 9, 12, and 17 presented significant anti-metastasis activities compared with the positive reagent,
more » ... e reagent, LY294002. Molecules 2016, 21, 1283 2 of 12 Z-salignone (13) [13], terminamine H (14) [8], 3β-methylamino 16-oxo 5,17(20) trans-pregnadiene (15) [12], E-salignone (16) [13], and (+)-spiropachysine (17) [14] (Figure 1 ). Structures of 1-9 were determined based on the 1D-and 2D-NMR, and mass spectrometric analytical results.
doi:10.3390/molecules21101283 pmid:27681716 fatcat:tk2xbxtdazbtfdav5yuaswoyte