Porphyrin, which forms the basic skeleton of important colour materials (hem, chlorophyll,etc.) shows the ability to accumulate in vivo in cancer cells. While the discovery of new functional molecules for application of photodynamic therapy and drug delivery systems has been actively researched, the effect of functional porphyrin positions has not been investigated. In this study, we evaluated the accumulation in cancer cells of porphyrin containing a hydrophilic functional group (polyethylene

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... lycol), and found that the hydrophilicity of the functional group and its position in porphyrin affected the accumulation.