Genomic and transcriptomic alterations associated with drug vulnerabilities and prognosis in adenocarcinoma at the gastroesophageal junction

Yuan Lin, Yingying Luo, Yanxia Sun, Wenjia Guo, Xuan Zhao, Yiyi Xi, Yuling Ma, Mingming Shao, Wen Tan, Ge Gao, Chen Wu, Dongxin Lin
2020 Nature Communications  
AbstractAdenocarcinoma at the gastroesophageal junction (ACGEJ) has dismal clinical outcomes, and there are currently few specific effective therapies because of limited knowledge on its genomic and transcriptomic alterations. The present study investigates genomic and transcriptomic changes in ACGEJ from Chinese patients and analyzes their drug vulnerabilities and associations with the survival time. Here we show that the major genomic changes of Chinese ACGEJ patients are chromosome
more » ... y promoted tumorigenic focal copy-number variations and COSMIC Signature 17-featured single nucleotide variations. We provide a comprehensive profile of genetic changes that are potentially vulnerable to existing therapeutic agents and identify Signature 17-correlated IFN-α response pathway as a prognostic marker that might have practical value for clinical prognosis of ACGEJ. These findings further our understanding on the molecular biology of ACGEJ and may help develop more effective therapeutic strategies.
doi:10.1038/s41467-020-19949-6 pmid:33257699 fatcat:6ujbxvtzybenfaadcearhe245q