Matrix metalloproteinase 9, superoxide dismutase and lipid peroxidation in preterm newborns with perinatal hypoxia

Yu. V. Korenovsky, S. A. Elchaninova, N. I. Fadeyeva
2011 Bûlleten' Sibirskoj Mediciny  
The perinatal hypoxia (PH) in preterm newborns is associated with elevated levels of matrix metalloproteinase 9 (MMP-9), superoxide dismutase (SOD) and thiobarbituric acid reactive substances in umbilical cord blood plasma. The severity of PH Apgar scores correlated with SOD (r = –0,40; p = 0,006) and MMP-9 (r = 0,36; p = 0,023). It is assumed that the SOD increase prevents the reactive oxygen species mediated activation of MMP-9, which destroy the collagen of the basement membrane of the
more » ... mbrane of the bloodbrain barrier.
doi:10.20538/1682-0363-2011-2-26-29 fatcat:fznybgxnl5egtorivy4z2as454