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Hcpatic a nd splenic amyloidosis was experimentally induced by casein injections in BA LB; C mice and examincd biochemically for glycosaminoglycan constituents. Heparan sulfate and dermatan sulfate were shown to be major components by clectrophoresis on cellulose acetate membrane. It was demonstrated from the studies of DEAE-eellulose ion-exchanging chromatography that the amount of highly sulfated derma tan sulfate was increased in amyloid-laden liver and that the amount of highly sulfatedpmid:3923358 fatcat:mp32e2ulx5ah5ougqlyf5c6qu4