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In the present study, describes the Studies on development and evaluation of sustained release matrix tablets containing tizanidine. Were prepared by wet-granulation method using polymers like Guar gum & Ethyl cellulose in different ratios. Matrix tablet evaluated by different methods for parameters such as hardness,weight, thickness, drug content uniformity. The tablets were evaluated for in vitro release in pH 1.2 and 7.4 phosphate buffer for 12 hours in standard dissolution apparatus. Indoi:10.5281/zenodo.3585630 fatcat:4rwrzpppkvcqzlzh6oz3uu6dja