Schizophrenia is a psychiatric disorder that develops in relatively younger age groups. In Japan, the geriatric population continues to grow, and thus, the proportion of elderly patients with schizophrenia is increasing. Pharmacotherapy with antipsychotics is the primary treatment for schizophrenia. Additionally, antipsychotics are also effective against behavioral and psychological symptoms of dementia, which increases the chance of prescribing these drugs to elderly patients with dementia.

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... ever, in elderly people, drug-induced dysuria is likely to occur, and the most well-known triggers of this dysuria are drugs' anticholinergic effects. Thus, it is necessary to predict to what extent antipsychotics cause this type of dysuria. In this study, we examined the possible inhibitory effects of 26 commercially available and clinically used antipsychotics on ACh-induced contraction in isolated rat UBSM. Among them, pipamperone, sulpiride, sultopride, tiapride, nemonapride, risperidone, paliperidone, aripiprazole, and brexpiprazole did not significantly affect ACh-induced contraction, suggesting that these antipsychotics are unlikely to cause anticholinergic effects-associated dysuria. Poster Sessions