Responsiveness to high intensity interval training depends on insulin sensitivity and protein content and composition of small extracellular vesicles [post]

Maria Apostolopoulou, Lucia Mastrototaro, Sonja Hartwig, Dominik Pesta, Klaus Strassburger, Elisabetta de Filippo, Tomas Jelenik, Yanislava Karusheva, Sofiya Gancheva, Daniel Markgraf, Christian Herder, Sreekumar Nair (+5 others)
2020 unpublished
High intensity interval training (HIIT) improves cardiorespiratory fitness (VO2max), but its impact on metabolism remains unclear. We hypothesized that 12-week HIIT improves insulin sensitivity in people with or without type 2 diabetes (T2D, NDM). However, despite identically improved VO2max, mainly insulin-resistant persons (T2D, IR NDM) responded with improved insulin sensitivity and circulating small extracellular vesicles (SEV), along with reduced myocellular protein kinase Cε activity
more » ... se Cε activity (T2D) or inflammation (IR NDM). These changes related to the SEV proteome, characterized by downregulated phospholipase C pathway (T2D) and upregulated antioxidant capacity (IR NDM). Thus, SEV cargo likely contributes to modulating exercise responsiveness in humans.
doi:10.21203/ fatcat:5gyqtm4af5a3jfuvvpm4vghmpq