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Biopolymers and Cell
AML1 and ETO genes are known partners in the t (8, 21) translocation associated with the treatment-related leukaemias in the patients receiving chemotherapy with DNA-topoisomerase II (topo II) poisons. Aim. To determine whether the genes AML1 and ETO are in close proximity either permanently or temporarily in the nucleus. Methods. 3D FISH. Results. We found that in 5 % of untreated cells, alleles of AML1 and ETO are in close proximity. This number increased two-fold in the cells treated withdoi:10.7124/bc.00012d fatcat:bpwlcntlt5gcrahahix7jaegbu