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Pif1 DNA helicase is a potent unwinder of Gquadruplex (G4) structures in vitro and functions to maintain genome stability at G4 sequences in Saccharomyces cerevisiae. Here, we developed and utilized a live-cell imaging approach to quantitatively measure the progression rates of single replication forks through different G4 containing sequences in individual yeast cells. We show that in the absence of Pif1, replication rates through specific lagging strand G4 sequences in vivo is significantlydoi:10.1093/nar/gky1065 pmid:30395308 fatcat:u3cxaqrfmze77nrlb3zlu7towy