In-silico screening of active molecules from medicinal plant resources for controlling SARS-CoV-2 infection

Rajdeep Ghosh, GSL Medical College and General Hospital, NH 16, Lakshmipuram, Rajahmundry-533296, India, Satadru Palbag, Debasish Ghosh, ISM Drugs Control, 205, Vivekananda Road, Kolkata-700006. India, Vishwanath AyurvedMahavidhyalaya And Hospital, 94, Grey Street, Kolkata, India
2020 Journal of Ayurvedic and Herbal Medicine  
The entire human population is under treat of SARS-Cov-2 virus causing life threatening complicacies. Three proteins namely papain-like protease (PLpro), 3C-like protease (3CLpro) and spike protein isolated from the virus have been targeted for formulating the antiviral medicament. Ayurvedic medicinal plants with established antiviral efficacy are great choice to design immediate treatment strategies in this trying time. Here, 9 active molecules from ayurvedic medicinal plant resources were
more » ... resources were selected, out of which only 6 have screened through ADME analysis and molecular docking was performed with the three viral proteins to understand their antiviral performances in in silico model. Outcome of this study will surely open up a floodgate of thousand new possibilities in exploiting the existing natural herbs in COVID 19 treatments.
doi:10.31254/jahm.2020.6310 fatcat:bzu3ytzr4bezdf6zf45gpjnb4a