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Plasma profiles of glucose, insulin and lipids were examined in the male WBN/Kob-Lepr fa (fa/fa) rat, a new model of type 2 diabetes (T2D), in comparison with age-matched original male WBN/Kob (lean) rats. The fa/fa rats developed hypertriglycemia, obesity and hyperglycemia from 5, 7, and 9 weeks of age, respectively. Plasma insulin levels in fa/fa rats were significantly higher than those in lean rats at 5 weeks of age, but after 11 weeks of age gradually declined to the levels in lean rats.doi:10.1292/jvms.12-0045 pmid:22571894 fatcat:jccqqv6ilzdnnftav32bfrttcu