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In this small review, we recall two promising candidates for biomarker nanosystems, in which a two-site defect embedded in a diamond-like lattice makes a single-photon source. The two candidates are the silicon-vacancy defect in diamond, and the carbon antisite-vacancy pair in 4H silicon carbide. These defects, which by symmetry resemble to the famous nitrogen-vacancy defect in diamond, bear an exact or nearly exact C 3v symmetry, giving them selection rules which lead their importantdoi:10.1051/epjconf/20147805001 fatcat:v7s7ujcgofedxpkunntw5cn4je