Serum Clara Cell Protein: A Sensitive Biomarker of Increased Lung Epithelium Permeability Caused by Ambient Ozone

Fabrice Broeckaert, Karim Arsalane, Cedric Hermans, Enrico Bergamaschi, Angelita Brustolin, Antonio Mutti, Alfred Bernard
2000 Environmental Health Perspectives  
Ozone in ambient air may cause various effects on human health, induding decreased lung function, asthma excerbation, and even premature mortality. These efficts hav been evidenced using various dinical indicators at,altho sensitive, donot' s ficay elate the 0-incresed lung epitheliu'm pebility. In the present study, we :assessed the acu'te effes of ambient 03 on the pullmonay epitheium by a new approach relying on the assay in serum of e lung-speific Clara cell protein (CPC16 o C:CI')). We
more » ... 6 o C:CI')). We applied tis test t'o cclists who eercised for 2 r during episodes of photochemical smog and found that 03 induces an early lage of lung Ca ell proteini. The protein levels increased significantly into the serum from etposure levels as low as 0.060-0.084 ppm. 0)ur findings, confirmed in mice exposedl to the current U.S. National Ambient Air Quality Stindards for 0,3 (0.08 ppm for 8 ir) indicate that above the present natural boackground leels; there is almost no safety margin for the eif ofanbient 03 on airway permeability. The: assay of CC16 ini the serum represents a new sensitite noninvaive test aBlowing the den of ea:lfo ambient 03 on the lg epite barier. Key.woor biomarker, CC10, CC16, Cl cell protein, epitheium, lung persneabili'ty ozone. Envion Healtb Pmnpect
doi:10.2307/3454615 fatcat:qx37dutdm5dtheabz67m5erkpm