Alok Mishra, Ashutosh Shrivastava, Anshuman Srivastava, Sudhir Kumar Verma
2019 Journal of Evidence Based Medicine and Healthcare  
BACKGROUND Iodothyronine deiodinases type 1, 2 and 3 (DIO1, DIO2 and DIO3) are enzymes that activates and deactivate Thyroid Hormones (TH) maintaining their homeostasis at cellular level. Recent studies show a possible role of deiodinases in various cancers. In this manuscript; we used data mining analytical approach and studied the prognostic significance DIO1-3 in Breast Cancer. METHODS Prognostic values of DIO1-3 were predicted using the "Kaplan-Meier Plotter" (KM plotter) database for
more » ... database for direct in silico validation in clinical cases of breast cancer patients. After extracting KM survival plots, Relapse Free Survival (RFS) were compared, and Hazard Ratio (HR) and log-rank p-values were calculated. RESULTS There was a significant change in RFS of ER-ve breast cancer patients, with high DIO1 and DIO2 expression. Further, ER+ve breast cancer with hormone therapy high expression of DIO3 results in significantly poor RFS. CONCLUSIONS We found limited potential of prognostic values of DIO1-3 in breast cancer. We conclude that in some subgroups of breast cancer, these findings may be beneficial as a companion diagnostic predicting more accurate breast cancer prognosis. HOW TO CITE THIS ARTICLE: Mishra A, Shrivastava A, Srivastava A, et al. Prognostic significance of deiodinase enzymes MRNA expression in breast cancer.
doi:10.18410/jebmh/2019/479 fatcat:cjlt4zfrxrei3dkfpfqxkqjska