Antinociceptive and Anti-Inflammatory Properties of Daucus carota Seeds Extract

Mani Vasudevan, Kumar Kishore Gunnam, Milind Parle
2006 Journal of health science  
The ethanolic extract of Daucus carota seeds (DCE) was investigated for anti-inflammatory and analgesic activity at the doses [per oral (p.o.)] of 100, 200 and 400 mg/kg body weight. For evaluation of inflammation carrageenan-, histamine-and serotonin-induced paw edema served as acute models and formaldehyde-induced arthritis served as a chronic model in rats. The acetic acid-induced writhing response and formalin-induced paw licking time in the early and late phases of mice were used to assess
more » ... were used to assess analgesic activity. The higher doses of DCE (200 and 400 mg/kg, p.o.) were inhibiting carrageenan, histamine and serotonin-induced paw edema as well as formaldehyde-induced arthritis successfully. In addition, DCE (200 and 400 mg/kg, p.o.) significantly attenuated the writhing responses induced by an intraperitoneal injection of acetic acid and late phase of pain response induced by an subplantar injection of formalin in mice. Pharmacological studies showed that Daucus carota seeds (DCE) exhibit antifertility properties. 7,8) The crude extract of root of the plant has been found to be hypoglycemic 9) and hepatoprotective. 10) Cholinergic activity was also found in water-soluble fraction of the alcoholic extract of seeds. 11) Different parts of this plant are used in Indian systems of medicine for the treatment of a broad spectrum of aliments including kidney dysfunction, asthma, dropsy, inflammation, leprosy and worm troubles. 12,13) Whether these claims are valid is a subject of great interest and should be probed scientifically. With this aim we carried out an investigation of this plant's potential as an anti-inflammatory and analgesic in rodents.
doi:10.1248/jhs.52.598 fatcat:cwgldsv2ybfovnc7tqhjsrgrt4