219 Galangin, a dietary flavonoid reduces mitochondrial damage in streptozotocin-induced diabetic rats

Khalid S Alnumair, Chinnadurai Veeramani, Chandramohan Govindasamy, Mohammed A Alsaif
2017 Heart  
AngII infusion caused two-fold increase in ROS production of WT hearts (p<0.05) (but not p47 phox KO mice), which was inhibited significantly by diphenyleneiodonium (DPI, a flavoprotein inhibitor) or superoxide dismutase, significantly but slightly by NG-nitro-l-arginine methyl ester (L-NAME, a nitric oxide synthase inhibitor), but not by rotenone (mitochondrial respiratory chain inhibitor) or oxypurinol (xanthine oxidase inhibitor). Increased ROS production in WT AngII-infused hearts was
more » ... ed hearts was accompanied by significant phosphorylation of ERK1/2. In conclusion, p47 phox and p47 phox signalling through ERK1/2 play an important role in AngII-induced cardiac hypertrophy.
doi:10.1136/heartjnl-2017-311726.217 fatcat:n7teja6qnfhvzhb2j4lvp7ktqa