Copper based metallo drugs were prepared and their antibacterial, antifungal, molecular mechanism of [Cu(SAla)Phen]AEH 2 O and [Cu(SAla)bpy]AEH 2 O complexes were investigated. The [Cu(SAla)Phen]AEH 2 O and [Cu(SAla)bpy]AEH 2 O were derived from the Schiff base alanine salicylaldehyde. [Cu(SAla)Phen]AEH 2 O showed noteworthy antibacterial and antifungal activity than the [Cu(SAla)bpy]AEH 2 O and ligand alanine, salicylaldehyde. The [Cu(SAla)Phen]AEH 2 O complex showed significant antibacterial

more »

... ctivity against Salmonella typhi, Staphylococcus aureus, Salmonella paratyphi and the antifungal activity against Candida albicans and Cryptococcus neoformans in well diffusion assay. The mode of action of copper (II) complex was analyzed by DNA cleavage activity and in silico molecular docking. The present findings provide important insight into the molecular mechanism of copper (II) complexes in susceptible bacterial and fungal pathogens. These results collectively support the use of [Cu(SAla)Phen]AEH 2 O complex as a suitable drug to treat bacterial and fungal infections. ª 2011 Production and hosting by Elsevier B.V. on behalf of King Saud University.