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Co-evolution is a fundamental aspect of Evolutionary Theory. At the molecular level, co-evolutionary linkages between protein families have been used as indicators of protein interactions and functional relationships from long ago. Due to the complexity of the problem and the amount of genomic data required for these approaches to achieve good performances, it took a relatively long time from the appearance of the first ideas and concepts to the quotidian application of these approaches anddoi:10.3389/fcell.2014.00014 pmid:25364721 pmcid:PMC4207036 fatcat:dgsepmbscrga5ansj2gkp3v7dy