Characteristics of the Clinical Findings in Patients with Idiopathic Thrombocytopenic Purpura Who are Positive for Anti-phospholipid Antibodies

Masanori FUNAUCHI, Kinnya HAMADA, Hiroshi ENOMOTO, Shinnya IKOMA, Motoki OHNO, Koji KINOSHITA, Atsushi HORIUCHI
1997 Internal medicine (Tokyo. 1992)  
It has been reported that anti-phospholipid antibodies are detected in some patients with idiopathic thrombocytopenic purpura (ITP). To study the significance of determination of antiphospholipid antibodies in patients with ITP, clinical and laboratory findings were compared between patients whose sera were positive for these antibodies (Group A) and non-positive patients (Group B). Anti-cardiolipin antibody (aCL) was determined by enzyme-linked immunosorbent assay and lupus anticoagulant (LA)
more » ... anticoagulant (LA) was determined by activated partial thromboplastin time (aPTT) and thromboplastin time inhibition test. Seven out of27 cases ofITP belonged to Group A and 3 of the 7 were confirmed to have anti-phospholipid antibody syndrome (APS). There was a tendency for habitual abortion, and thrombosis, megakaryocytes in the bone marrow and plateletassociated IgG (PAIgG)-positive cells were more frequent in Group A than in Group B. However, it was difficult to discriminate APSfrom ITP alone, whenthere were no symptomsor signs ofAPS. Therefore, measurement of anti-phospholipid antibodies in ITP was thought to be useful for the differential diagnosis of APS and subsequently for the prevention of thrombosis. (Internal Medicine 36: 882-885, 1997)
doi:10.2169/internalmedicine.36.882 fatcat:57r26b542fgx7jhwqwtrvw7spm