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Stem cell differentiation is governed by extracellular signals that activate intracellular networks (or pathways) to drive phenotypic specification. Using a novel gene clustering strategy we determined pathway relationships from a genome-wide transcriptional dataset of skeletal myoblast differentiation. Established myogenic pathways, including cell contractility and cell-cycle arrest, were predicted with extreme statistical significance ( p å 0). In addition, gene sets associated withdoi:10.1016/j.ygeno.2005.08.009 pmid:16300922 fatcat:uatrjxctdvbz7cl4agntkfytni