Novel Coumarin Derivatives Containing 1,2,4-Triazole, 4,5-Dicyanoimidazole and Purine Moieties: Synthesis and Evaluation of Their Cytostatic Activity

Krešimir Benci, Leo Mandić, Tomislav Suhina, Mirela Sedić, Marko Klobučar, Sandra Kraljević Pavelić, Krešimir Pavelić, Karlo Wittine, Mladen Mintas
2012 Molecules  
We report here on the synthesis and in vitro anti-tumor effects of a series of novel 1,2,4-triazole (compounds 3-6), 4,5-dicyanoimidazole (compound 7), and purine (compounds 8-13) coumarin derivatives and their acyclic nucleoside analogues 14-18. Structures of novel compounds 3-18 were deduced from their 1 H-and 13 C-NMR and corresponding mass spectra. Results of anti-proliferative assays performed on a panel of selected human tumor cell lines revealed that compound 6 had moderate cytostatic
more » ... erate cytostatic activity against the HeLa cell line (IC 50 = 35 µM), whereas compound 10 showed moderate activity against the HeLa (IC 50 = 33 µM), HepG2 (IC 50 = 25 µM) and SW620 (IC 50 = 35 µM) cell lines. These compounds showed no cytotoxic effects on normal (diploid) human fibroblasts.
doi:10.3390/molecules170911010 pmid:22971585 fatcat:qb23xwaz25h6rhihivdgcaochi