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Breast metastases from extramammary carcinomas are very rare. Primary anorectal melanoma is a rare and aggressive disease with poor prognosis. Despite aggressive surgery, the 5-year survival is less than 10%. Primary anorectal melanoma metastasis to the breast is exceptional. Only two cases were reported in literature. We present a case of breast metastase from primary anorectal melanoma successfully managed with surgery and chemotherapy with longterm free survival. We also briefly reviewed thedoi:10.4021/jmc2010.06.104e fatcat:lxuqxtspwbcgdkc6umwonweq5q