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Although statins are remarkably effective, they are still underprescribed because of concerns about muscle toxicity. We review the aspects of statin myopathy that are important to the primary care physician and provide a guide for evaluating patients on statins who present with muscle complaints. We outline the differential diagnosis, the risks and benefits of statin therapy in patients with possible toxicity, and the subsequent treatment options.doi:10.3949/ccjm.78a.10073 pmid:21632911 fatcat:3m5oew7x2fhhxh7ytwgzxicugy