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Down's Syndrome or Trisomy 21 is the most common chromosomal abnormality occurring in human leading to mental retardation and stunted growth. It is considered as a genetic disorder with a defect in all or a part of a third copy of chromosome 21. This article highlights varied clinical presentation of 18 year old patient with Down's Syndrome.doi:10.31254/jmr.2017.3304 fatcat:7v4ik66dhrdh3nqq2buy7ifddi