The 100 most influential studies in CAR-T: a bibliometric analysis
Bibliometric analyses are used to provide information on trends within a specific research field, along with indicators of the impact of a publication. With such an analysis, we map the scientific landscape of chimeric antigen receptor T-cell (CAR-T) research to see the emerging topics and infer directions the field might take. Methods: We extracted the 100 most cited articles, published between 1945 to 2018, from the Web of Science Core Collection. Using their bibliographic details, including
... details, including year of publication, country of author, funding agencies, research organization, author information, and keywords, we graph the networks created between the articles. Results: Of the 100 papers identified, majority (92%) were written in the United States. US government agencies and non-profit organizations provided the most funding. It was observed that the papers funded by the NIH had the most citations, followed by those funded by the Alliance for Cancer Gene Therapy. Also notable was that 33 papers were published from the University of Pennsylvania. Regarding authors, Carl H. June participated in 30 researches, followed by Bruce L. Levine who participated in 11. As for journals, Blood (n=20) published the most papers, followed by Science Translational Medicine (n=10). Lastly, the most frequently used keywords were "adoptive immunotherapy" (n=37), "lymphocytes" (n=27), and "antitumor-activity" (n=25). Conclusion: By evaluating the top 100 most cited papers in the CAR-T field, this study provides insight into the direction of the scientific growth and its trends, as well as information on the field's network structure.