5-[Substituted]-1, 3, 4-thiadiazol-2-amines: Synthesis, Spectral Characterization, and Evaluation of their DNA interactions

N. Shivakumara, P. Murali Krishna
2019 Current Chemistry Letters  
The presence of heterocyclic moiety in diverse compounds, strongly indicative of the desired effect on physiological activity, and it reflects on efforts to find useful synthetic drugs. In this connection, here reporting the synthesis and characterization of 5-[substituted]-1, 3, 4thiadiazol-2-amines (1-7). All the prepared compounds were characterized by spectroscopic methods viz. 1 H-NMR, 13 C{ 1 H}-NMR, FT-IR, and LC-MS. The results of the DNA binding interactions using absorption and
more » ... sorption and fluorescence spectroscopy reveal that the compounds are avid binders to DNA. A DNA cleavage study with pUC18 DNA using gel electrophoresis indicates the compounds are able to cleave DNA in presence of oxidant H2O2.
doi:10.5267/j.ccl.2019.4.004 fatcat:ebhjt4vyereklcca4eklhfornq