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The use of loss function in studying the reduction in determinant of information matrix due to missing observations has effectively produced designs that are robust to missing observations. Modified central composite designs are constructed for non-standard models using principles of the loss function or equivalently first compound of (I ) matrix associated with hat matrix . Although central composite designs (CCDs) are reasonably robust to model mis-specifications, efficient designs with fewerdoi:10.5539/ijsp.v7n5p95 fatcat:mxmgssalqva37dx4rjoeqmtyzm