The effect of allopurinol on the progression of chronic kidney disease

Aygul Ozdemir, Ayca Inci
2017 Journal of Nephropharmacology  
Hyperuricemia has been associated with the development of hypertension, cardiovascular, and renal disease. Objectives: We conducted a prospective study to investigate the benefits of allopurinol treatment in hyperuricemic patients with chronic kidney disease (CKD) stage 3. Patients and Methods: Our study includes a total of 132 patients (41 females and 91 males) with CKD grade 3 who are followed up by the pre-dialysis polyclinic. Around 67 of these patients administered allopurinol while 65
more » ... urinol while 65 patients were not administered. The therapy protocol for the patients was allopurinol 150 mg/d and the duration of the follow-up was 12 months. Clinical records of the patients were screened, to start with 3, 6, 9 and 12 months, eGFR (estimated glomerular filtration rate) values were calculated. Results: The patients' eGFR with allopurinol treatment was increased compared with baseline values. 12th month increased by 1.02 ± 8.89 mL/min/1.73 m 2 from baseline in eGFR, but it was not statistically significant (P = 0.352). In the control group 12th month showed a decrease in baseline GFR value of 2.59 ± 7.9 mL/min/1.73 m 2 (P = 0.012). The 3, 6, 9, 12th months compared with baseline in the allopurinol treatment group showed a significant decrease in uric acid value (P < 0.05). Conclusion: Decreased renal progression was observed by reduction of serum uric acid levels at stage 3 hyperuricemic CKD with allopurinol. The annual decline in GFR in hyperuricemic patients, is more than normouricemic patients.
doi:10.15171/npj.2017.21 fatcat:4fcbx4iklrd6lfe4og2dfban7e