Review on Newly Identified Corona Virus and its Genomics Organization

Keertana Rao, Poonam Verma, Krishan Kumar, Manish Kr Verma, Areena Hoda Siddiqui, Sunita Singh, Jagmohan Singh Dhakar, Cansu Ilke Kuru, Parshant Kumar Sharma, Navneet Omprakash Soni, Sagar Aryal
2020 International Journal of Life-Sciences Scientific Research  
Human Coronaviruses (HCoV) exhibit positive single stranded RNA genome with enveloped nucleocaps id. Coronavirus belong to the family Coronaviridae, originated from avian and mammalian species causes upper respiratory tract infection in humans by novel HCoVs viruses named as HCoV-HKU1, HCoV-NL63 but predominant species is Middle East respiratory syndrome (MERS-CoV) across the world. HCoV-HKU1 sp. is associated with chronic pulmonary disease, while HCoV-NL63 causes upper and lower respiratory
more » ... ower respiratory tract disease in both children and adults, but most recent one was MERS-CoV, which caused acute pneumonia and occasional renal failure. The novel coronavirus SARS-CoV-2 is a new strain that causes the Coronavirus Disease 2019 (COVID-19) as named by the Word Heath Organization. According to the recent world statistics report about the COVID-19 cases approx. 101,500 confirmed cases and 3,500 death cases appeared. And mostly, a case of infection with CoV was identified in Wuhan, China. Structurally viral genome constitutes of 2/3rd of replicase gene encoding ORFs regions and rest of the 1/3rd region of genome form the structural proteins. The aim of the study was to understand the viral genetic systems in order to facilitate the genetic manipulation of the viral genome and to know the fundamental mechanism during the viral replication, facilitating the development of antidotes against the virus.
doi:10.21276/ssr-iijls.2020.6.2.5 fatcat:fuccfsfsvjbe5fs2zzeehngmbu