Study of Serum Vitamin D Level among Critically Ill Patients Admitted to Alexandria University Pediatric Intensive Care Unit
Journal of Medical Science And clinical Research
Vitamin D is a pleiotropic hormone that plays an important role in calcium homeostasis, bone health, cardiovascular system and immunity. Vitamin D has other roles in the body, including modulation of cell growth, neuromuscular and immune functions, and reduction of inflammation. Its deficiency may aggravate the incidence and outcome of infectious complications in critically ill patients. Aim: The aim of this work was to determine the frequency of vitamin D deficiency in critically ill patients
... cally ill patients admitted to pediatric intensive care unit [PICU], Alexandria university children's hospital (AUCH) and relate the state of serum 25(OH) D to disease severity. Methods: Study was carried out on 102 critically ill children admitted to PICU at AUCH. Blood was collected on PICU admission and analyzed for 25(OH) D concentration by using enzyme linked immunosorbent assay (ELISA) kits. Results: Low vitamin D levels had been found in most of our patients where 37.3% of cases were vitamin D deficient and 38.2% of cases were vitamin D insufficient while only 24.5 % of cases were vitamin D sufficient. High Pediatric logistic organ dysfunction (PELOD) score and high alkaline phosphatise (ALP) were associated with 25(OH)D deficiency while summer season and sun exposure were protective. There was no significant difference according to vitamin D level as regards PICU stay, patient mortality, presence of sepsis or septic shock and main affected system on admission. Conclusion: We found a high rate of vitamin D deficiency in critically ill children and vitamin D level was negatively correlated with PELOD score. We recommend screening of critically ill children for vitamin D deficiency to restore their serum levels.