Gender Differences in the Treatment of Acute Coronary Syndromes: Results From the Epi-Cardio Registry
Diferencias de género en el tratamiento de los síndromes coronarios agudos: Los resultados de la Epi-Cardio Registro

Javier Mariani, Laura Antonietti, Carlos Daniel Tajer, Maximiliano De Abreu, Adrián Charask, Mario Silberstein, Juan Gagliardi, Hernán C. Doval
2013 Revista Argentina de Cardiología  
Controversial evidence has been reported regarding gender bias in the management of patients with acute coronary syndromes; thus, it is relevant to have data related to this topic in our country. Objective The aim of this study was to assess gender differences in the management of acute coronary syndromes in cardiovascular care units participating in the Epi-Cardio registry. Methods We included 8997 records of patients with diagnosis of acute coronary syndromes. Propensity score adjusted
more » ... ore adjusted analyses and sensitivity analysis were performed. Results In patients with non ST-segment elevation acute coronary syndromes, women were independently associated with lower in-hospital indication of coronary angiography (OR 0.73, 95% CI 0.65 to 0.82), and lower use of IIb/IIIa inhibitors than men. After adjusted analyses, there were no significant differences between men and women in the use of reperfusion therapy for myocardial infarction or in in-hospital mortality. At discharge, women were significantly less likely than men to receive prescriptions for beta-blockers and statins, and more likely to receive prescriptions for benzodiazepines. Conclusions These findings suggest gender bias in the treatment of patients with acute coronary syndromes, evidenced by selection of a more conservative strategy and lower prescription of drugs recommended for secondary prevention in women. Differences between genders in the approach of acute coronary syndromes should be studied more deeply, as the underutilization of evidence-based therapies could have an impact on women's clinical outcomes. REV ARGENT CARDIOL 2013;81:287-295. http://dx.doi.org/10.7775/rac.v81.i4.2330
doi:10.7775/rac.v81.i4.2330 fatcat:kelyws4rrbhvdmo7immvolzz24