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Multiple Sclerosis (MS) decreases the quality of life of the patients. This study aimed to evaluate the effect of acceptance and commitment therapy (ACT) on cognitive fusion, cognitive and anxiety symptoms, and quality of life in the female patients with MS. Materials and Methods: 50 female patients with MS were randomly assigned to receive ACT and life skills training (LSE). ACT treatment was performed for 8 consecutive weeks and each session was 90 minutes for the intervention group. The datadoaj:d5b4c4d5a8a843e6ad2b13fe5aa3a6a7 fatcat:dxneaeahg5ejbp72vgvrv667hm