Platelet function and indices in Lithuanian men with dyslipidemia: associations with inflammatory biomarkers

Valdas Banys, Viktorija Andrejevaitė, Virginijus Šapoka, Zita Aušrelė Kučinskienė
2015 Acta medica Lituanica  
Introduction. Platelet function, platelet volume indices, traditional markers of lipid me tabolism, inflammatory markers and a novel biomarker, cyclophilin A (CyPA), are related as far as they have implications in pathogenesis of atherosclerosis. The purpose of this study was to evaluate interrelations among these factors, correlation between platelet function and inflammatory factors, also a function of CyPA. Materials and methods. 160 male patients with high risk of atherosclerosis and
more » ... clerosis and metabolic syndrome were included in the study. Inclusion criteria were as follows: distur bances in lipids profile, increased weight, smoking, acute or chronic stress, no previous or current acute cardiovascular disease (CVD), high risk and presence of stress confirmed by physician. CRP, vWF, fibrinogen, CyPA levels were measured. Platelet function was as sessed by aggregation and flow cytometry. Results. Increasing number of risk factors gave statistically significant elevation in fi brinogen, thrombin receptors activating peptide, CRP, glucose, mean platelet volume (MPV), platelet large cell ratio, lipids and their ratios with extremely significant linearity. MPV correlated positively with CD42a (r = 0.605; p < 0.001) and negatively with CD42a/CD14 (r = -0.327; p < 0.001). Lipid ratios were found to be prognostic for metabolic syndrome bio chemical markers. Platelet function parameters showed relation with lipid ratios, lipidCRP ratios, MPV and vWF. CyPA correlated with CD42a/CD14 (r = 0.202, p = 0.010). Conclusions. Platelets in men with dyslipidemia and other investigated risk factors have a tendency to be hyperreactive. It might be considered as a separate risk factor for CVD. Inflammatory status does not correlate with the platelet function. CyPA reflects inflammatory processes but not the platelet function. Abbreviations: AI -atherogenic index; CD14 -cluster of differentiation 14 (mono cyte differentiation antigen); CD42a -cluster of differentiation 42a (glycoprotein IX); CD63 -cluster of differentiation 63 (type III lysosomal glycoprotein, expressed on activat ed platelets, monocytes and macrophages); CyPA -cyclophilin A; HDLC -high density lipoprotein cholesterol; hsCRP -Creactive protein high sensitivity assay; CVD -cardio vascular diseases; LDLC -low density lipoprotein cholesterol; MPV -mean platelet volume; MS -metabolic syndrome; PAC1 -antibodies against an epitope on the gly coprotein IIb/IIIa (gpIIb/IIIa, αIIbβ3) complex of activated platelets; Pct -plateletcrit; PDW -platelet distribution width; PLT -platelet count; PLCR -platelet large cell ratio; TC -total cholesterol; G -triglycerides; TRAP -thrombin receptors activating peptide; vWF -von Willebrand factor
doi:10.6001/actamedica.v21i4.3048 fatcat:gdxqfao6enafxk4ujrmnaljksy