MORPHOLOGICAL CHANGES IN HUMAN FETAL SPLEEN AT DIFFERENT GESTATIONAL AGES
International Journal of Anatomy and Research
The purpose of the study was desired to investigate and observe the variations in the morphology of spleen in human fetuses. The spleen is the largest secondary lymphoid organ, in the fetal stage it also performs the role of haematopoiesis. It acts as a blood filter, and also acts as storage site for iron, erythrocytes, and platelets. Materials and Methods: This study has been carried out on spleen of 40 formalin preserved human fetuses (19 males and 21 females) of different gestational ages,
... gestational ages, in the Department of Anatomy, Government Medical College, Haldwani over a period of two years (i.e. 2014-2016), with due regards on ethical grounds. Various gross parameters of spleen such as its location, shape, relations, notches & fissures and ligaments were observed and the results were statistically analyzed. Results: Spleens in all the fetuses was located in the left hypochondrium. 60% of the fetal spleens were wedge shaped. While stomach was related to the spleen in all the gestational ages, kidney and left colic flexure were not related to the spleen in the early age of the fetus. Liver and left adrenal gland also showed relations with the fetal spleen. Maximum number of notches was present in the superior border followed by inferior border and lateral pole. Fissures were also seen in 11 spleens. Conclusion: Knowledge about prenatal ontogenesis of the spleen will help to understand the mechanisms of pathology in the organ and create methods of diagnosis and prevention.