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Mimicking the Structure of the V3 Epitope Bound to HIV-1 Neutralizing Antibodies†
2009
Biochemistry
The third variable region (V3) of the HIV-1 envelope glycoprotein gp120 is a target for virus neutralizing antibodies. The V3 sequence determines whether the virus will manifest R5 or ×4 phenotypes and use the CCR5 or C×CR4 chemokine co-receptor, respectively. Previous NMR studies revealed that both R5-and ×4-V3 peptides bound to antibodies 0.5β and 447-52D form β-hairpin conformations with the GPGR segment at the turn. In contrast, in their free form, linear V3 peptides and a cyclic peptide
doi:10.1021/bi802308n
pmid:19281264
pmcid:PMC2756766
fatcat:fuwva5pq7zh7zdlrqfpkmyjj4q