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I tried this preparation, and found it answer the description. Out of twenty persons who took it, none complained of headache or unpleasant sequences. But it was not of a good color, and soon grew muddy, and seemed to be decomposed. 1 therefore made some modifications of the preparation, until I fixed upon the following formula, which answers admirably, and makes and retains the beautifully red and clear form of that which I herewith send you. I use no other preparation of opium, except thedoi:10.1056/nejm185001090412309 fatcat:xti4w6yofbgx5nfl2qnda4k3w4