Bone Mineral Density Reference Values and Prevalence of Osteoporosis in Singaporean Adults – The Yishun Study [post]

Kexun Chen, Shiou-Liang Wee, Benedict Wei Jun Pang, Lay Khoon Lau, Khalid Abdul Jabbar, Wei Ting Seah, Sivasubramanian Sriniva, Jagadish Ullal Mallya, Tze Pin Ng
2020 unpublished
Background: While there have been studies in Singapore on the prevalence and economic burden of osteoporotic hip fracture, there is a severe lack of reference data on bone mineral density and prevalence of osteoporosis. The purpose of this study is to establish the reference values for BMD and compare prevalence of osteoporotic conditions using other available reference values so as to better understand the status of bone health in Singaporean adultsMethods: We carried out a population-based
more » ... population-based cross-sectional study using dual-energy x-ray absorptiometry (Hologic Discovery Wi) to measure the bone mineral density of Singaporean adults aged ³ 21 years. 314 women and 223 men were recruited from the large north-eastern residential town of Yishun. We computed T- scores (denoted by TSG) for each individual in the study. Similar diagnoses were also done based on T-scores provided by the densitometer (TDXA), NHANES database (TNHANES), and China (TCHN), and the differences in prevalence compared. We then compared the concordance between TSG and TDXA in the classification of osteoporosis. Osteoporosis was defined according to criteria by the World Health Organization (WHO).Results: Peak lumbar spine BMD was 1.090±0.168g.cm-2 in women, and 1.041±0.098g.cm-2 for men. Peak whole body BMD was 1.193±0.93g.cm-2 in women at, and 1.224±0.112g.cm-2 for men. Prevalence of osteoporosis based on lumbar spine was 9.3% in women, and 0.7% in men. The percentage difference in prevalence range from 60.5 - 163.6%, when using reference values from TDXA, TNHANES, and TCHN. Among the 28 women who were diagnosed as osteoporotic by TDXA, 16.5% only had osteopenia according to TSG. The kappa statistics was 0.81 for women and 0.85 for men. Conclusion: Our study shows that T-scores provided by DXA manufacturer over-diagnosed osteoporosis in Singaporeans, and the prevalence of osteoporotic conditions is not accurately represented. This over-diagnosis may result in unnecessary treatment in some individuals.
doi:10.21203/rs.3.rs-37206/v1 fatcat:iyuqudmwtrfxzngutpgifrjq3u