Segmenting Motifs in Protein-Protein Interface Surfaces [chapter]

Jeff M. Phillips, Johannes Rudolph, Pankaj K. Agarwal
2006 Lecture Notes in Computer Science  
Protein-protein interactions form the basis for many intercellular events. In this paper we develop a tool for understanding the structure of these interactions. Specifically, we define a method for identifying a set of structural motifs on protein-protein interface surfaces. These motifs are secondary structures, akin to α-helices and β-sheets in protein structure; they describe how multiple residues form knob-intohole features across the interface. These motifs are generated entirely from
more » ... etric properties and are easily annotated with additional biological data. We point to the use of these motifs in analyzing hotspot residues.
doi:10.1007/11851561_20 fatcat:ejgxxnocbza2vackq6vpkm65ai