Effect of long-acting gestagen levonorgestrel butanate on the spermatogenesis and endocrine function of the adrenals and gonads of papio hamadrias

N. P. Goncharov, G. V. Katsiya, V. Yu. Butnev, V. M. Gorlushkin
1996 Problemy Endokrinologii  
Tlie efficacy of levonorgestrel butanate in doses 1, 2, 4, and 8 mg/kg in spermatogenesis suppression was studied in adult male Papio hamadrias. The drug was injected intramuscularly twice with 3 month interval. All gestagen doses had an inhibitory effect of spermatogenesis, this effect increasing with the dosage build-up. None of the animals developed azoospermia, which was due to incomplete suppression of the pituitary gonadotropic function and of testosterone secretion. Hormonal
more » ... rmonal concentration in the peripheral blood was 55-60% reduced in response to the minimal dose and 60-80% reduced in response to the maximal dose. Injection of long-acting gestagen did not influence the secretion of adrenocortical hormones hydrocortisone, dehydroepiandrosterone, and pregnenolone.
doi:10.14341/probl11922 fatcat:o3iskvzthndr5cdeqtrqfsnfwm