Annonamine, a New Aporphine Alkaloid from the Leaves of Annona muricata

Ayano Matsushige, Yaichiro Kotake, Katsuyoshi Matsunami, Hideaki Otsuka, Shigeru Ohta, Yoshio Takeda
2012 Chemical and pharmaceutical bulletin  
Atypical Parkinsonism in the Caribbean Island Guadeloupe is thought to be associated with the consumption of plants of the Annonaceae family, especially Annona muricata (soursop). In this study, a new aporphine alkaloid named annonamine (1) was isolated from the leaves of A. muricata L. together with four known benzylisoquinoline alkaloids (2-5). The structures of the isolated compounds were elucidated by the spectroscopic method.
doi:10.1248/cpb.60.257 pmid:22293487 fatcat:so5zvjkd7fbp3kylq3j22mlwti